Effects of COVID-19 Lockdown on Weight, Body Composition, and Behavior of Children, Adolescents, and Young Adults with Prader–Willi Syndrome

Autor:	Bettina Gohlke, Constanze Laemmer, Sandra Schulte, Andrea Mohr
Rok vydání:	2021
Předmět:	congenital hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Prader–Willi syndrome physical activity eating behavior Growth hormone Article genetic obesity Age groups medicine Young adult business.industry nutritional and metabolic diseases COVID-19 General Medicine nervous system diseases growth hormone Lean body mass Medicine Early adolescents business Body mass index
Zdroj:	Journal of Clinical Medicine, Vol 10, Iss 4746, p 4746 (2021) Journal of Clinical Medicine Volume 10 Issue 20
ISSN:	2077-0383
DOI:	10.3390/jcm10204746
Popis:	To reduce transmission of the coronavirus disease 2019 (COVID-19), many countries implemented lockdowns, causing the closure of childcare services. This study was designed to evaluate the impact of the COVID-19 lockdown in March–April 2020 on children, adolescents, and young adults with Prader–Willi syndrome (PWS) living in Germany. We recruited 180 participants with a genetically confirmed PWS. All families completed a questionnaire, and participants underwent a post-lockdown assessment the last examination before the lockdown was determined as the pre-lockdown assessment. We used bivariate analyses to compare pre- and post-lockdown outcomes. Weight standard deviation scores (SDSPWS) and body mass index (BMI)-SDSPWS remained stable or even decreased in some age groups. A statistically significant gain in lean body mass (LBM) was found in all groups < 18 years of age. We observed an increase in IGF-I and IGFBP-3 concentrations without a significant change in growth hormone (GH) dosage. Most families (95.4%) reported set mealtimes and implementation of structured activities (72.2%) during the lockdown period. We therefore suggest that the favorable development of weight/BMI and LBM was caused by an interplay of a suspected enhanced GH administration and continuous parental commitment. However, more intense behavioral problems were observed in 45.7%, which persisted post-lockdown in 33.7%.
Databáze:	OpenAIRE
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