Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association
| Autor: | Bettina Kulle, Albert Rosenberger, Heike Bickeböller, Nico Janicke, Karola Köhler, Katrin Korb |
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| Rok vydání: | 2005 |
| Předmět: |
genetic structures
Genetic Linkage Genome-wide association study Alcohol use disorder Biology behavioral disciplines and activities Polymorphism Single Nucleotide 01 natural sciences Genome Statistics Nonparametric 010104 statistics & probability 03 medical and health sciences Genetic linkage Polymorphism (computer science) Surveys and Questionnaires Genetics medicine Humans Genetics(clinical) Genetic Predisposition to Disease 0101 mathematics Association (psychology) Evoked Potentials Genetics (clinical) 030304 developmental biology Linkage (software) Behavior 0303 health sciences Siblings medicine.disease Phenotype 3. Good health Proceedings Chromosomes Human Pair 2 Lod Score Alcohol-Related Disorders Genome-Wide Association Study Microsatellite Repeats |
| Zdroj: | BMC Genetics |
| ISSN: | 1471-2156 |
| DOI: | 10.1186/1471-2156-6-s1-s55 |
| Popis: | For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads. |
| Databáze: | OpenAIRE |
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