Palladium-Catalyzed Asymmetric Allylic Alkylation of 4-Substituted Isoxazolidin-5-ones: Straightforward Access to β 2,2 -Amino Acids
| Autor: | Dozova, Nadia, Pousse, Guillaume, Barnych, Bogdan, Mallet, Jean-Maurice, Valeur, Bernard, Plaza, Pascal, Nascimento de Oliveira, Marllon, Arseniyadis, Stellios, Cossy, Janine |
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| Přispěvatelé: | Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
[PHYS]Physics [physics] 010405 organic chemistry Organic Chemistry Enantioselective synthesis chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences 3. Good health Amino acid Stereocenter Beta-lactam chemistry.chemical_compound Tsuji–Trost reaction chemistry [CHIM]Chemical Sciences ComputingMilieux_MISCELLANEOUS Palladium |
| Zdroj: | Chemistry-A European Journal Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (19), pp.4810-4814. ⟨10.1002/chem.201800641⟩ |
| ISSN: | 0947-6539 1521-3765 |
| DOI: | 10.1002/chem.201800641⟩ |
| Popis: | We report here an unprecedented and highly enantioselective palladium-catalyzed allylic alkylation applied to 4-substituted isoxazolidin-5-ones. Ultimately, the process provides a straightforward access to β2,2 -amino acids bearing an all-carbon quaternary stereogenic center in great yields and a high degree of enantioselectivity. |
| Databáze: | OpenAIRE |
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