Usefulness of the addition of metformin to insulin in pediatric patients with type 1 diabetes mellitus
Autor: | Shigeo Morimoto, Tatsuhiko Urakami, Kensuke Harada, Misao Owada |
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Rok vydání: | 2005 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent endocrine system diseases medicine.medical_treatment Overweight Body Mass Index Pharmacotherapy Diabetes mellitus Internal medicine medicine Humans Hypoglycemic Agents Insulin Adverse effect Glycated Hemoglobin Type 1 diabetes business.industry nutritional and metabolic diseases medicine.disease Metformin Diabetes Mellitus Type 1 Endocrinology Pediatrics Perinatology and Child Health Drug Therapy Combination Female medicine.symptom business Body mass index medicine.drug |
Zdroj: | Pediatrics International. 47:430-433 |
ISSN: | 1442-200X 1328-8067 |
Popis: | BACKGROUND The aim of this study was to evaluate the effect of metformin in addition to insulin therapy in adolescents and young adults with type 1 diabetes mellitus. METHODS Nine patients, two males and seven females, aged 18.1 +/- 3.0 years, with type 1 diabetes mellitus were studied. They were relatively overweight with a body mass index (BMI) of 24.2 +/- 1.8 and had high levels of HbA1c at 9.5 +/- 1.2% despite high doses of insulin of 74.0 +/- 31.2 U/day. Metformin at the dose of 500-750 mg daily was administered to the patients in addition to insulin therapy for 1 year. RESULTS HbA1c, BMI and insulin dose were compared before 1 year without metformin therapy, at baseline, and at 3, 6 and 12 months during the use of metformin in addition to insulin therapy. HbA1c lowered (8.6 +/- 1.4**, 8.4 +/- 1.3**, 8.4 +/- 1.2*%), BMI was reduced (23.9 +/- 1.7*, 23.8 +/- 1.8, 23.5 +/- 1.8*), and insulin requirement decreased (69.8 +/- 29.7*, 68.7 +/- 29.8**, 67.3 +/- 29.1**U/d) significantly after the start of metformin therapy (*P < 0.05, **P < 0.01 vs at baseline). There were no adverse events, not even lactic acidosis, during the study period. CONCLUSION Metformin is safe and may represent a useful adjunct to the management of type 1 diabetes mellitus in adolescents and young adults who have poor glycemic control despite a large amount of insulin. |
Databáze: | OpenAIRE |
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