Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer
| Autor: | Kimiko Sogabe, Shingen Nakamura, Ryohei Sumitani, Masami Yoshioka, Yuka Sogawa, Makoto Fukui, Masahiro Abe, Daisuke Hinode |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Saliva medicine.medical_treatment Antineoplastic Agents Neutropenia Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine stomatognathic system Risk Factors Internal medicine Humans Medicine Risk factor Aged Febrile Neutropenia Aged 80 and over Mouth Chemotherapy Hematology Fusobacterium nucleatum biology business.industry Cancer Middle Aged medicine.disease biology.organism_classification Bacterial Load stomatognathic diseases Hematologic Neoplasms 030220 oncology & carcinogenesis Immunoglobulin A Secretory Female Anaerobic bacteria business 030215 immunology |
| Zdroj: | International Journal of Hematology. 112:851-859 |
| ISSN: | 1865-3774 0925-5710 |
| Popis: | The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject were assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the Cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink