The multi‐functional RNA‐binding protein G3BP1 and its potential implication in neurodegenerative disease
Autor: | Alicia Dubinski, Hadjara Sidibé, Christine Vande Velde |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
G3BP1 translation Context (language use) RNA-binding protein Disease Review Biology Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Stress granule neurodegenerative disease Animals Humans Stress granule assembly mRNA stability Poly-ADP-Ribose Binding Proteins Binding protein DNA Helicases RNA‐binding proteins Translation (biology) Neurodegenerative Diseases Non-coding RNA 030104 developmental biology RNA Recognition Motif Proteins ALS Neuroscience 030217 neurology & neurosurgery RNA Helicases |
Zdroj: | Journal of Neurochemistry |
ISSN: | 1471-4159 0022-3042 |
Popis: | Ras‐GTPase‐activating protein (GAP)‐binding protein 1 (G3BP1) is a multi‐functional protein that is best known for its role in the assembly and dynamics of stress granules. Recent studies have highlighted that G3BP1 also has other functions related to RNA metabolism. In the context of disease, G3BP1 has been therapeutically targeted in cancers because its over‐expression is correlated with proliferation of cancerous cells and metastasis. However, evidence suggests that G3BP1 is essential for neuronal development and possibly neuronal maintenance. In this review, we will examine the many functions that are carried out by G3BP1 in the context of neurons and speculate how these functions are critical to the progression of neurodegenerative diseases. Additionally, we will highlight the similarities and differences between G3BP1 and the closely related protein G3BP2, which is frequently overlooked. Although G3BP1 and G3BP2 have both been deemed important for stress granule assembly, their roles may differ in other cellular pathways, some of which are specific to the CNS, and presents an opportunity for further exploration. G3BP1 (Ras‐GTPase‐activating protein (GAP)‐binding protein 1) is a multi‐functional protein involved in the assembly and dynamics of stress granules, and also other functions related to RNA metabolism. G3BP1 has been therapeutically targeted in cancers as its over‐expression is correlated with the proliferation of cancerous cells and metastasis. However, evidence suggests that G3BP1 is essential for neuronal development and possibly neuronal maintenance. The current Review examines the various functions of G3BP1 in the context of neurons, and we speculate how these functions are critical to the progression of neurodegenerative diseases. Additionally, we will highlight the similarities and differences, some of which are specific to the CNS, between G3BP1 and the closely related protein G3BP2, with a particular focus on stress granule assembly. |
Databáze: | OpenAIRE |
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