Decreased Retinal Thickness in Type 1 Diabetic Children with Signs of Nonproliferative Diabetic Retinopathy
| Autor: | P. Alemany Márquez, Alfonso M. Lechuga-Sancho, Almudena Alonso-Ojembarrena, Pablo Ruiz-Ocaña, P. Espinoza Requena, S. Jiménez Carmona |
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| Přispěvatelé: | [Ruiz-Ocana, P.] Univ Hosp Puerta del Mar, Dept Pediat, Diabet & Metab Unit, Cadiz, Spain, [Lechuga-Sancho, A. M.] Univ Hosp Puerta del Mar, Dept Pediat, Diabet & Metab Unit, Cadiz, Spain, [Espinoza Requena, P.] Univ Hosp Puerta del Mar, Dept Ophthalmol, Cadiz, Spain, [Alemany Marquez, P.] Univ Hosp Puerta del Mar, Dept Ophthalmol, Cadiz, Spain, [Jimenez Carmona, S.] Univ Hosp Puerta del Mar, Dept Ophthalmol, Cadiz, Spain, [Alonso-Ojembarrena, A.] Univ Hosp Puerta del Mar, Dept Pediat, Neonatol Unit, Cadiz, Spain, [Alemany Marquez, P.] Cadiz Univ, Sch Med, Dept Surg, Cadiz, Spain, [Jimenez Carmona, S.] Cadiz Univ, Sch Med, Dept Surg, Cadiz, Spain, [Lechuga-Sancho, A. M.] Cadiz Univ, Sch Med, Dept Mother & Child Hlth & Radiol, Cadiz, Spain |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Microvascular complications Article Subject Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Adolescents lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Edema Ophthalmology Prevalence Medicine Variability Domain Retina Type 1 diabetes lcsh:RC648-665 Optical coherence tomography Endocrine and Autonomic Systems business.industry Retinal Odds ratio Diabetic retinopathy medicine.disease Reproducibility Risk-factors medicine.anatomical_structure Nerve-fiber layer Oct chemistry Metabolic control analysis Cohort 030221 ophthalmology & optometry medicine.symptom business Research Article |
| Zdroj: | International Journal of Endocrinology International Journal of Endocrinology, Vol 2018 (2018) Europe PubMed Central |
| ISSN: | 1687-8337 |
| Popis: | The retina functions as a neurovascular unit. How early vascular alterations affect neuronal layers remains controversial; early vascular failure could lead to edema increasing retinal thicknesses, but alternatively neuronal loss could lead to reduced retinal thickness. Objective. To evaluate retinal thickness in a cohort of pediatric patients with type 1 diabetes mellitus (PwT1DM) and to analyze differences according to the presence or absence of nonproliferative diabetic retinopathy (NPDR), poor metabolic control, and diabetes duration. Patients and Methods. We performed retinographies and optical coherence tomography (OCT) (TOPCON 3D1000®) to PwT1DM followed at our center and healthy controls. Measurements of the control group served to calculate reference values. Results. 59 PwT1DM (age 12.51 ± 2.59) and 22 healthy controls (age 10.66 ± 2.51) volunteered. Only two PwT1DM, both adolescents with poor metabolic control, presented NPRD. Both showed decreased thicknesses and retinal volumes. The odds ratio of having decreased retinal thickness when signs of NPDR were present was 11.72 (95% IC 1.16–118.28; p=0.036). Conclusions. PwT1DM with NPDR have increased odds of decreased retinal thicknesses and volumes. Whether these changes are reversible by improving metabolic control or not remains to be elucidated. |
| Databáze: | OpenAIRE |
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