Sesquiterpenoids from the aerial parts of Conyza japonica and their inhibitory activity against nitric oxide production
| Autor: | Si-Chen Zhang, Lin-Kun An, Hong-Li Zhang, Lu Liu, Yu Zhang, Long-Gao Xiao, Qian Yu |
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| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
Models Molecular Circular dichroism Stereochemistry Conyza japonica Nitric Oxide Inhibitory postsynaptic potential 01 natural sciences Nitric oxide Mice chemistry.chemical_compound Drug Discovery Ic50 values Animals Cytotoxicity Inflammation Pharmacology chemistry.chemical_classification Molecular Structure 010405 organic chemistry General Medicine Plant Components Aerial 0104 chemical sciences 010404 medicinal & biomolecular chemistry Hepatoma cell line RAW 264.7 Cells chemistry Conyza Sesquiterpenes Lactone |
| Zdroj: | Fitoterapia. 142:104473 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2020.104473 |
| Popis: | Four new sesquiterpenoids, conyterpenols A − D (1–4), along with nineteen known analogues (5–23) were isolated from the aerial parts of Conyza japonica. The structures of 1–4 were determined through spectroscopic analysis, while their absolute configurations were determined by comparison of calculated and experimental electronic circular dichroism (ECD) spectra. Conyterpenol D (4) was a new type of sesquiterpenoid with a seven-membered lactone ring. Compounds 1–23 were evaluated for their inhibitory activity against LPS-induced nitric oxide production in RAW264.7 macrophages and cytotoxicity against human hepatoma cell line (HepG2) and human breast adenocarcinoma cell line (MCF-7). Compounds 3, 4, and 12 displayed moderate inhibition against NO production with IC50 values in the range of 26.4–33.6 μM. And all compounds showed no obvious cytotoxicity against these two cancer cell lines at 100 μM. |
| Databáze: | OpenAIRE |
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