Diminished supraspinal pain modulation in patients with mild traumatic brain injury
| Autor: | Eric Yang, Bryan Canlas, Jason Heald, Mawj Kadokana, Shivshil Shukla, Ariea Davani, Alice Tsai, Roland R. Lee, Albert Leung, Lisa Lin, David D. Song, Greg Polston |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Traumatic Image Processing Brain mapping 0302 clinical medicine Computer-Assisted Traumatic brain injury Injury - Trauma - (Head and Spine) Brain Injuries Traumatic Neural Pathways Image Processing Computer-Assisted 2.1 Biological and endogenous factors resting state functional connectivity 030212 general & internal medicine Aetiology Brain Mapping medicine.diagnostic_test Diffuse axonal injury Pain Research Brain Pain Perception Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Anesthesia Neurological Molecular Medicine Female Chronic Pain Psychology Research Article Adult Thalamus Pain chronic posttraumatic headaches 03 medical and health sciences Cellular and Molecular Neuroscience Clinical Research mild traumatic brain injury medicine Humans Anterior cingulate cortex Neurology & Neurosurgery supraspinal pain processing Neurosciences medicine.disease functional magnetic resonance imaging Brain Disorders Dorsolateral prefrontal cortex Anesthesiology and Pain Medicine Brain Injuries Chronic Disease Injury (total) Accidents/Adverse Effects Biochemistry and Cell Biology Functional magnetic resonance imaging Injury - Traumatic brain injury Insula Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Molecular Pain |
| Popis: | Background Chronic pain conditions are highly prevalent in patients with mild traumatic brain injury. Supraspinal diffuse axonal injury is known to dissociate brain functional connectivity in these patients. The effect of this dissociated state on supraspinal pain network is largely unknown. A functional magnetic resonance imaging study was conducted to compare the supraspinal pain network in patients with mild traumatic brain injury to the gender and age-matched healthy controls with the hypothesis that the functional connectivities of the medial prefrontal cortices, a supraspinal pain modulatory region to other pain-related sensory discriminatory and affective regions in the mild traumatic brain injury subjects are significantly reduced in comparison to healthy controls. Results The mild traumatic brain injury group (N = 15) demonstrated significantly (P 150 voxels) less activities in the thalamus, pons, anterior cingulate cortex, insula, dorsolateral prefrontal cortex, and medial prefrontal cortices than the healthy control group (N = 15). Granger Causality Analyses (GCA) indicated while the left medial prefrontal cortices of the healthy control group cast a noticeable degree of outward (to affect) causality inference to multiple pain processing related regions, this outward inference pattern was not observed in the mild traumatic brain injury group. On the other hand, only patients’ bilateral anterior cingulate cortex received multiple inward (to be affected) causality inferences from regions including the primary and secondary somatosensory cortices and the inferior parietal lobe. Resting state functional connectivity analyses indicated that the medial prefrontal cortices of the mild traumatic brain injury group demonstrated a significantly (P 150 voxels) higher degree of functional connectivity to the inferior parietal lobe, premotor and secondary somatosensory cortex than the controls. Conversely, the anterior cingulate cortex of the healthy group demonstrated significantly (P 150 voxels) less degree of functional connectivities to the inferior parietal lobe and secondary somatosensory cortex than their mild traumatic brain injury counterparts. Conclusions In short, the current study demonstrates that patients with mild traumatic brain injury and headaches appear to have an altered state of supraspinal modulatory and affective functions related to pain perception. |
| Databáze: | OpenAIRE |
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