DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage
| Autor: | Ray Truant, Laura E Bowie, Tamara Maiuri |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Huntingtin DNA Repair DNA repair DNA damage Biology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Huntington's disease Genetics medicine Huntingtin Protein Animals Humans Molecular Biology Neurodegeneration Neurodegenerative Diseases Cell Biology General Medicine medicine.disease Cell biology Oxidative Stress 030104 developmental biology 030220 oncology & carcinogenesis Spinocerebellar ataxia Oxidative stress DNA Damage Signal Transduction |
| Zdroj: | DNA and cell biology. 38(1) |
| ISSN: | 1557-7430 |
| Popis: | A new hypothesis for the mechanism of Huntington's disease (HD) is driven by a small molecule lead that may connect age-associated reactive oxygen stress, oxidative DNA damage, and mitochondrial dysfunction. These pathways have also recently been defined in genome-wide association studies of cytosine-adenine-guanine-expansion polyglutamine neurodegenerative diseases, including HD and the spinocerebellar ataxias. We discuss how N6-furfuryladenine (N6FFA) nucleotide salvage and role as a kinase neosubstrate may have important mechanistic implications for both HD and familial Parkinson's disease. N6FFA highlights a mechanism of how energy dysregulation and protein misfolding in neurodegeneration may be the effect of age-associated reactive oxygen species damage to DNA and part of a feedback loop augmenting with aging. |
| Databáze: | OpenAIRE |
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