Synthesis of Suspected Carcinogenic Metabolites of 7H-Benzo[c]fluorene, a Coal Tar Component Implicated in Causation of Lung Tumors
| Autor: | Ronald G. Harvey, Eric H. Weyand, Ji-Quan Wang |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Lung Neoplasms
Magnetic Resonance Spectroscopy Stereochemistry Metabolite Epoxide Fluorene DNA Adducts Mice chemistry.chemical_compound Tar (tobacco residue) polycyclic compounds medicine Animals Coal tar Coal Tar Active metabolite Carcinogen Fluorenes Molecular Structure Organic Chemistry Stereoisomerism DNA Benzo(c)fluorene chemistry Biochemistry Carcinogens medicine.drug |
| Zdroj: | The Journal of Organic Chemistry. 67:6216-6219 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/jo011149b |
| Popis: | High incidences of lung tumors were observed in mice fed coal tar in their diet. The principal component of tar that gives rise to DNA-bound adducts in mouse lung was identified as 7H-benzo[c]fluorene (BcF). We now report the synthesis of suspected active metabolites of BcF, specifically the trans-3,4-dihydrodiol of BcF (2), its likely proximate carcinogenic metabolite, and the corresponding anti- and syn-diol epoxides of BcF (3 and 4) in which the epoxide ring resides in the pseudobay region. The diol epoxide derivatives (3 and 4) are postulated to be ultimate carcinogenic metabolites of BcF that bind to DNA in mouse lung. |
| Databáze: | OpenAIRE |
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