Late onset of the serological response against the 18 kDa small heat shock protein of Mycobacterium ulcerans in children
| Autor: | Eric Koka, Katharina Röltgen, Jacques C. Minyem, Djeunga Noumen, Martin W. Bratschi, James Pritchard, Kobina Assan Ampah, Alphonse Um Boock, Gerd Pluschke, Amanda Ross, Dorothy Yeboah-Manu, Samuel Yaw Aboagye, Arianna Andreoli, Miriam Bolz |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Buruli ulcer Endemic Diseases Ghana Immunoglobulin G Serology Seroepidemiologic Studies Medicine and Health Sciences Cameroon Child Immune Response Buruli Ulcer lcsh:Public aspects of medicine Antibodies Bacterial Bacterial Pathogens Infectious Diseases Medical Microbiology Child Preschool Mycobacterium ulcerans Female Surface protein Research Article Adult lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 Immunology Late onset Biology Microbiology Young Adult Bacterial Proteins Age groups Heat shock protein parasitic diseases medicine Humans Microbial Pathogens Antigens Bacterial Infant Newborn Public Health Environmental and Occupational Health Biology and Life Sciences Infant lcsh:RA1-1270 biology.organism_classification medicine.disease Heat-Shock Proteins Small Emerging Infectious Diseases biology.protein |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2904 (2014) PLoS Neglected Tropical Diseases |
| Popis: | A previous survey for clinical cases of Buruli ulcer (BU) in the Mapé Basin of Cameroon suggested that, compared to older age groups, very young children may be less exposed to Mycobacterium ulcerans. Here we determined serum IgG titres against the 18 kDa small heat shock protein (shsp) of M. ulcerans in 875 individuals living in the BU endemic river basins of the Mapé in Cameroon and the Densu in Ghana. While none of the sera collected from children below the age of four contained significant amounts of 18 kDa shsp specific antibodies, the majority of sera had high IgG titres against the Plasmodium falciparum merozoite surface protein 1 (MSP-1). These data suggest that exposure to M. ulcerans increases at an age which coincides with the children moving further away from their homes and having more intense environmental contact, including exposure to water bodies at the periphery of their villages. Author Summary Although M. ulcerans, the causative agent of Buruli ulcer (BU), was identified in 1948, its transmission pathways and environmental reservoirs remain poorly understood. The occurrence of M. ulcerans infections in endemic countries in West and Central Africa is highly focal and associated with stagnant and slow flowing water bodies. BU is often described as a disease mainly affecting children |
| Databáze: | OpenAIRE |
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