High Adherence to a Gluten-Free Diet in Adolescents With Screening-Detected Celiac Disease
| Autor: | Lotta Högberg, Anna Myléus, Anneli Ivarsson, Carina Lagerqvist, Solveig Hammarroth, Lars Stenhammar, Fredrik Norström, Annelie Carlsson, Charlotta Webb, Olof Sandström, Anna Rosén |
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| Rok vydání: | 2015 |
| Předmět: |
Pediatrics
medicine.medical_specialty Adolescent Biopsy Population Child Behavior Disease Cohort Studies Diet Gluten-Free GTP-Binding Proteins Intestine Small Humans Mass Screening Medicine Protein Glutamine gamma Glutamyltransferase 2 Intestinal Mucosa Child education Autoantibodies Sweden education.field_of_study Transglutaminases business.industry Gastroenterology nutritional and metabolic diseases digestive system diseases Immunoglobulin A Celiac Disease Cross-Sectional Studies Adolescent Behavior Pediatrics Perinatology and Child Health Patient Compliance Gluten free Self Report business Biomarkers Follow-Up Studies |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 60:54-59 |
| ISSN: | 0277-2116 |
| DOI: | 10.1097/mpg.0000000000000571 |
| Popis: | The aim of the study was to evaluate the gluten-free diet (GFD) adherence after 1 year of follow-up in children with screening-detected celiac disease (CD) in a general population.A total of 18,325 twelve-year-olds were invited to participate in a population-based CD screening (Exploring the Iceberg of Celiacs in Sweden), of whom 13,279 participated. In 240 children, CD was detected through elevated anti-tissue transglutaminase antibodies 2 (TG2-IgA) and verified by a small-intestinal biopsy. This substudy included 210 children with TG2-IgA, evaluated both at the initial biopsy occasion and at 1-year follow-up. GFD adherence was evaluated by a combination of TG2-IgA measurements and self-reported adherence (n = 193).After 1 year, 85% (179/210) had normalized TG2-IgA levels (5 U/mL). Among those who had50 U/mL at diagnosis, 25% (16/63) still had elevated TG2-IgA, but for the majority their initial values were more than halved. Most reported a high level of GFD adherence ("always" 82% [158/193] and "often" 16% [30/193]), and 75% [145/193] reported always adhering combined with normalized TG2-IgA. Although reporting that they were always adherent, 13 (6.7%) had not yet normalized their TG2-IgA levels completely; however, a majority of these initially had the highest TG2-IgA levels.GFD adherence is high in adolescents with CD detected by screening of the general population of Swedish 12-year-olds. Almost all of them had normalized serology and reported GFD adherence at the 1-year follow-up. A few adolescents who reported GFD adherence, however, had elevated TG2-IgA levels, suggesting more severe disease and/or nonadherence. |
| Databáze: | OpenAIRE |
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