Comparison of the effects of rutaecarpine on molecular subtypes of breast cancer

Autor:	Erdem Çokluk, Zeynep Ozman, Mehmet Ramazan Şekeroğlu, Gamze Guney Eskiler, Asuman Deveci Ozkan
Přispěvatelé:	ÖZMAN, Zeynep
Rok vydání:	2021
Předmět:	Vasodilator Agents Breast Neoplasms Triple Negative Breast Neoplasms Apoptosis Pharmacology Indole Alkaloids subtype breast cancer Breast cancer Tumor Cells Cultured medicine Humans Cytotoxic T cell Radiology Nuclear Medicine and imaging skin and connective tissue diseases Cell Proliferation biology Topoisomerase Cell Cycle Cancer General Medicine Rutaecarpine Cell cycle medicine.disease rutaecarpine Oncology Cancer cell Quinazolines biology.protein Female
Zdroj:	Journal of Cancer Research and Therapeutics. 17:988
ISSN:	0973-1482
Popis:	Objective: Natural compounds have gained considerable attention in recent years due to disadvantages and properties of current chemotherapy drugs in cancer therapy. In addition, the impact of these compounds is specific for each type and/or subtypes of cancer due to different treatment response. Rutaecarpine, an alkaloid obtained from Evodia Rutaecarpa Chinese herb, has anticancer activity by inhibiting topoisomerase and/or cyclo-oxygenase-2 levels. However, the effectiveness of rutaecarpine has not been well known in breast cancer in terms of subtype. Therefore, we investigated the potential therapeutic effects of rutaecarpine on two different subtypes of breast cancer cells. Materials and methods: The cytotoxic and apoptotic effects of rutaecarpine on MCF-7 and MDA-MB-231 cells were analyzed by WST-1, Annexin V, cell cycle, and acridine orange staining. Results: WST-1 results indicated that rutaecarpine significantly inhibited the growth of both cancer cells for 48 h (P < 0.05). In addition, rutaecarpine treatment caused apoptotic cell death through chromatin condensation and nuclear blebbing and G0/G1 arrest in both breast cancer cells. However, the efficacy of rutaecarpine was more profound in MCF-7 cells than MDA-MB-231 cells. Conclusions: Consequently, rutaecarpine has a potential therapeutic effect on breast cancer. However, the effectiveness of rutaecarpine is dependent on the subtype of breast cancer.
Databáze:	OpenAIRE
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