Long-term outcome in patients with acromegaly: analysis of 1344 patients from the German Acromegaly Register
| Autor: | Christof Schöfl, Holger Franz, Martin Grussendorf, Jürgen Honegger, Cornelia Jaursch-Hancke, Bernhard Mayr, Jochen Schopohl |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Reference range Disease Endocrinology Germany Internal medicine Epidemiology Acromegaly medicine Humans In patient Registries Insulin-Like Growth Factor I Aged Retrospective Studies Aged 80 and over business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease Radiation therapy Treatment Outcome Female business Rare disease |
| Zdroj: | European Journal of Endocrinology. 168:39-47 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-12-0602 |
| Popis: | BackgroundAcromegaly is a rare disease with significant morbidity and increased mortality. Epidemiological data about therapeutic outcome under ‘real life’ conditions are scarce.ObjectiveTo describe biochemical long-term outcome of acromegaly patients in Germany.Design and methodsRetrospective data analysis from 1344 patients followed in 42 centers of the German Acromegaly Register. Patients' data were collected 8.6 (range 0–52.6) years after diagnosis. Controlled disease was defined by an IGF1 within the center-specific reference range.ResultsNine hundred and seventeen patients showed a normalized IGF1 (157 (range 25–443) ng/ml). In patients with a diagnosis dated back >2 years (n=1013), IGF1 was normalized in 76.9%. Of the patients, 19.5% had an elevated IGF1 and a random GH ≥1 ng/ml, 89% of the patients had at least one surgical intervention, 22% underwent radiotherapy, and 43% received medical treatment. After surgery 38.8% of the patients were controlled without any further therapy. The control rates were higher in surgical centers with a higher caseload (P=0.034). Of the patients with adjunctive radiotherapy 34.8% had a normal IGF1 8.86 (0–44.9) years post irradiation, 65.2% of the medically treated patients were controlled, and 47.2% of the patients with an elevated IGF1 received no medical therapy.ConclusionThe majority of acromegaly patients were controlled according to their IGF1 status. Long-term outcome could be improved by exploiting medical treatment options especially in patients who are not controlled by surgery and/or radiotherapy. |
| Databáze: | OpenAIRE |
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