The functional link between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the onset of inflammation

Autor: Asif J. Iqbal, Gian Marco Casillo, Nicola Mascolo, Francesco Maione, Federica Raucci
Přispěvatelé: Maione, Francesco, Casillo, Gian Marco, Raucci, Federica, Iqbal, Asif J, Mascolo, Nicola
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
TXA(2)
(CID:5280497)
PPARγ
medicine.medical_treatment
13-HODE
(CID:6443013)
Anti-Inflammatory Agents
Peroxisome proliferator-activated receptor
12-HETE
(CID:5283154)
Pharmacology
chemistry.chemical_compound
0302 clinical medicine
PGE(2)
Receptor
PGD(2)
(CID:448457)
Prostaglandin-E Synthases
chemistry.chemical_classification
PGF(2α)
(CID:5280363)
Peroxisome
9-oxoODE
(CID:9839084)
030220 oncology & carcinogenesis
Arachidonic acid (CID:444899)
lipids (amino acids
peptides
and proteins)
9-HODE
(CID:5282945)
Inflammation Mediators
medicine.symptom
15-HETE
(CID:5280724)
LTB4
(CID:5280492)
Signal Transduction
Prostaglandin E
13-oxoODE
(CID:6446027)
Prostaglandin
Inflammation
5-HETE
(CID:5353349)
8-HETE
(CID:5283154)
03 medical and health sciences
LTE4
(CID:5280879)
medicine
Animals
Humans
PGI(2)
(CID:5282411)
PGE(2)
(CID:5280360)
Lipid signaling
mPGES-1
PPAR gamma
030104 developmental biology
Enzyme
LTC4
(CID:5280493)
chemistry
Popis: Many years have elapsed since the discovery of anti-inflammatories as effective therapeutics for the treatment of inflammatory-related diseases, but we are still uncovering their various mechanisms of action. Recent biochemical and pharmacological studies have shown that in different tissues and cell types lipid mediators from thearachidonic acid cascade, play a crucial role in the initiation and resolution of inflammation by shifting from pro-inflammatory prostaglandin (PG)E2 to anti-inflammatory PGD2 and PGJ2. Considering that until now very little is known about the biological effects evoked by microsomal prostaglandin E synthase-1 (mPGES-1) and contextually by peroxisome proliferator-activated receptor γ (PPARγ) modulation (key enzymes involved in PGE2 and PGD2/PGJ2metabolism), in this opinion paper we sought to define the coordinate functional regulation between these two enzymes at the "crossroads of phlogistic pathway" involved in the induction and resolution of inflammation.
Databáze: OpenAIRE
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