Serum apelin-36 levels in pre-diabetics and newly diagnosed diabetes mellitus patients
| Autor: | Özden Serin, İsmail Dağ, Erdinç Serin, Zeynep Mine Yalçinkaya Kara |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
pre-diabetic
medicine.medical_specialty endocrine system diseases medicine.medical_treatment 030204 cardiovascular system & hematology Carbohydrate metabolism Fibrinogen Gastroenterology Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine medicine 030212 general & internal medicine General Environmental Science lcsh:R5-920 diabetes business.industry Insulin nutritional and metabolic diseases Impaired fasting glucose medicine.disease diabet Apelin Newly diagnosed diabetes pre-diabet General Earth and Planetary Sciences lcsh:Medicine (General) business apelin 36 medicine.drug |
| Zdroj: | Cukurova Medical Journal, Vol 44, Iss 3, Pp 1094-1101 (2019) |
| ISSN: | 2602-3032 |
| Popis: | Purpose: The aim of this study was to investigate the levels of parameters for glucose metabolism and cardiovascular risk factors and apelin-36 in patients grouped as having impaired fasting glucose(IFG), IFG and impaired glucose tolerance(IGT), newly diagnosed type 2 DM and the control group.Materials and Methods: Fifty-three women and twenty-seven men, totally eighty subjects were enrolled in this study. The patients were classified into four groups according to their oral glucose tolerance test (OGTT) results. Group1: Normoglycemic controls(n:20), Group2: subjects with IFG(n:20), Group3: combined IFG subjects which included both IFG and IGT patients(n:20), Group4: Newly diagnosed type 2 DM patients(n:20). Levels of glucose, lipids, HbA1c, fibrinogen, insulin, cortisol, serum apelin-36 and C-peptide were analyzed.Results: There was a statistically significant difference regarding the levels of apelin-36 between group 1 and the study groups 2, 3 and 4, respectively. Other parameters analyzed for glucose metabolism and cardiovascular risk factors such as fasting glucose, HbA1c, HOMA-IR, fibrinogen, insulin, cortisol, C-peptide, LDL-cholesterol, HDL-cholesterol, VLDL-cholesterol, triglycerides, total cholesterol were significantly higher in the study groups when compared to the control group.Conclusion: In the future serum apelin-36 levels can be used as an indicator for presenting the insulin resistance and impairment in glucose metabolism in the early periods. |
| Databáze: | OpenAIRE |
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