New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity
| Autor: | Ruo-Fei Li, Si-Yuan Shao, Shuai Li, Hua Sun |
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| Rok vydání: | 2021 |
| Předmět: |
Ilex chinensis
Phytochemicals Ilex Protective Agents 01 natural sciences 03 medical and health sciences Hydrolysis chemistry.chemical_compound 0302 clinical medicine Triterpenoid Drug Discovery Humans Derivatization Sugar Hplc analysis Chromatography Molecular Structure 010405 organic chemistry Chemistry Hep G2 Cells General Medicine Saponins Triterpenes 0104 chemical sciences Plant Leaves Liver Complementary and alternative medicine 030220 oncology & carcinogenesis Hepg2 cells Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Chinese Journal of Natural Medicines. 19:376-384 |
| ISSN: | 1875-5364 |
| Popis: | Seven new triterpenoid saponins, including five ursane-type saponins, ilexchinenosides R–V ( 1 – 5 ), and two oleanane-type saponins, ilexchinenosides W–X ( 6 – 7 ), with four known triterpenoid saponins ( 8 – 11 ) were isolated from the leaves of Ilex chinensis. Their structures were elucidated by comprehensive spectroscopic 1D and 2D NMR and HR-ESI-MS data. Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization. Compounds 1 , 2 , 4 , 9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell injury in vitro. |
| Databáze: | OpenAIRE |
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