The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man
Autor: | Lars Knutson, Sten-Magnus Aquilonius, Lennart Paalzow, O. Ahrenstedt, Hans Lennernäs, Dag Nilsson |
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Rok vydání: | 1993 |
Předmět: |
Adult
Male medicine.medical_specialty Levodopa Absorption (skin) Intestinal absorption Jejunum Benserazide Leucine Internal medicine Intestine Small medicine Humans Pharmacology (medical) Pharmacology Chemistry digestive oral and skin physiology Stereoisomerism Hydrogen-Ion Concentration Small intestine Perfusion Endocrinology medicine.anatomical_structure Glucose Intestinal Absorption Paracellular transport Female Antipyrine medicine.drug Research Article |
Zdroj: | British journal of clinical pharmacology. 35(3) |
ISSN: | 0306-5251 |
Popis: | 1. A new method for perfusing a 10 cm segment of jejunum in humans has been used in seven subjects to study the effect of the amino acid L-leucine (40 mM) on the intestinal absorption of levodopa (2.5 mM). The tube contains six channels and has two inflatable balloons, which enable a perfusion of a closed and defined segment of the proximal small intestine. 2. L-leucine decreased the intestinal absorption of levodopa from 40 +/- 19 to 21 +/- 15% but was without effect on the absorption of antipyrine, benserazide and D-glucose. 3. We confirm that levodopa is absorbed by the active transport system normally responsible for the absorption of large neutral amino acids (LNAA) in humans. Oral absorption by passive diffusion, probably by the paracellular route, might also occur for levodopa in the proximal part of the small intestine. |
Databáze: | OpenAIRE |
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