Hyperoxia caused by microdialysis perfusion decreased striatal monoamines: involvement of oxidative stress
| Autor: | Xiao Yu, Peter G. Osborne, Huiwan Han, Dihua Shangguan, Lei Wang, Guoquan Liu, Rui Zhao |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis Hyperoxia medicine.disease_cause Cellular and Molecular Neuroscience chemistry.chemical_compound Dopamine Internal medicine Extracellular fluid medicine Animals Biogenic Monoamines Rats Wistar Chemistry Homovanillic acid Cell Biology Corpus Striatum Oxygen tension Rats Oxidative Stress Monoamine neurotransmitter Endocrinology Anesthesia medicine.symptom Oxidative stress medicine.drug |
| Zdroj: | Neurochemistry international. 42(6) |
| ISSN: | 0197-0186 |
| Popis: | Due to complex influence, such as utilization and permeability of arterial vessels to oxygen, there is a considerable difference of oxygen tension between extracellular fluid and perfusate usually used in microdialysis (30–60 Torr versus 145 Torr). Dialysate dopamine and monoamine metabolites—3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindoleacetic acid were measured under different kinds of oxygen tension solutions (145, 72, 48 Torr). In the acute and anesthetized group, dopamine, 3,4-dihydroxyphenylacetic acid, 5-hydroxyindoleacetic acid and homovanillic acid increased 72, 93, 86 and 65%, respectively when changing the perfusate from 145 Torr to near physiological 48 Torr, while in chronic and conscious group, carried out 72 h after surgery, these compounds showed obscure increases (only homovanillic acid produced a significant change of 14%). The different effect of perfusate oxygen tension on dialysate levels of monoamines in anesthetized and conscious rats might be caused by oxidative stress triggered by hyperoxia combined with anesthesia and surgical trauma. |
| Databáze: | OpenAIRE |
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