Recent advances on cellular therapies and immune modulators for graft-versus-host disease
| Autor: | Sergio Rutella, Perla Filippini |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
business.industry
medicine.medical_treatment Immunology Cell Hematopoietic Stem Cell Transplantation Graft vs Host Disease chemical and pharmacologic phenomena Disease Hematopoietic stem cell transplantation Immunotherapy Acquired immune system medicine.disease Proinflammatory cytokine Pathogenesis surgical procedures operative medicine.anatomical_structure Graft-versus-host disease Transplantation Immunology medicine Immunology and Allergy Humans business |
| Zdroj: | Expert review of clinical immunology. 10(10) |
| ISSN: | 1744-8409 |
| Popis: | The efficacy of allogeneic hematopoietic stem cell transplantation is counterbalanced by the occurrence of life-threatening immune-mediated complications, such as graft-versus-host disease (GVHD), a multistep disease which is reportedly fatal to approximately 15% of transplant recipients. It is now established that T-cell-dendritic cell interactions, T-cell activation, release of proinflammatory cytokines and T-cell trafficking partake in GVHD pathogenesis. This article will focus on the most recent strategies aimed at preventing/treating GVHD by manipulating components of the innate and adaptive immune response from both the donor and the host. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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