Lipoprotein(a) predicts progression of carotid artery intima-media thickening in patients with type 2 diabetes: A four-year follow-up
| Autor: | Spomenka Ljubić, Mladen Petrovecki, Jozo Boras, Zeljko Metelko, Nikica Car, Zeljko Reiner, Marijana Vučić Lovrenčić |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Croatia Blood Pressure Type 2 diabetes Gastroenterology Body Mass Index chemistry.chemical_compound Risk Factors Diabetes mellitus Internal medicine medicine Fibromuscular Dysplasia Humans Carotid Stenosis cardiovascular diseases Risk factor Triglycerides Aged Ultrasonography biology Triglyceride Waist-Hip Ratio business.industry Smoking lipoprotein(a) intima-media thickness diabetes mellitus carotid artery plaques cardiovascular risk Type 2 Diabetes Mellitus General Medicine Lipoprotein(a) Middle Aged medicine.disease Survival Rate Endocrinology Diabetes Mellitus Type 2 chemistry Intima-media thickness cardiovascular system biology.protein Female Tunica Intima Tunica Media business Diabetic Angiopathies Follow-Up Studies Lipoprotein |
| Zdroj: | Wiener klinische Wochenschrift. 122:159-164 |
| ISSN: | 1613-7671 0043-5325 |
| DOI: | 10.1007/s00508-010-1318-0 |
| Popis: | BACKGROUND: The aim of the study was to establish whether increased levels of serum lipoprotein(a) significantly contribute to an increase in intima-media thickness and the number of carotid artery plaques, and consequently to cardiovascular risk in patients with type 2 diabetes mellitus. METHODS: Lipoprotein(a) levels, intima-media thickness and the number of carotid artery plaques were determined at the beginning of the study in 146 patients with type 2 diabetes. Patients were divided into two groups according to serum lipoprotein(a) levels (> or ≤30 mg/dl). Intima-media thickness and the number of plaques were again determined after four years of follow-up. Intima-media thickness was assessed using high-resolution B-mode ultrasound. RESULTS: The two groups of patients revealed no significant differences in baseline intima-media thickness (P = 0.112) in relation to lipoprotein(a) level. After follow-up, intima-media thickness was significantly greater in patients with higher lipoprotein(a) levels (1.24 + 0.22 vs. 1.15 + 0.17 mm, respectively; P = 0.005). The mean increase in thickness over four years was 0.12 mm (0.030 mm/year) in the group with low lipoprotein(a) levels and 0.17 mm (0.043 mm/year) in the group with high lipoprotein(a). Multivariate analysis indicated that intima-media thickness depended on lipoprotein(a), and not on triglyceride, HDL-cholesterol levels or waist-to-hip ratio. No significant difference in baseline and follow-up number of plaques was observed between the study groups (P = 0.276 vs. P = 0.355, respectively). Although the group with lipoprotein(a) >30 mg/dl had more cardiovascular events, the difference was not statistically significant. CONCLUSIONS: These results indicate that lipoprotein(a) is an independent, genetically determined risk factor closely associated with progression of intima-media thickness in type 2 diabetes. |
| Databáze: | OpenAIRE |
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