Blunted basal corticosterone pulsatility predicts post-exposure susceptibility to PTSD phenotype in rats

Autor: Michael A. Matar, Joseph Zohar, Zeev Kaplan, Hagit Cohen, Dor Danan
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Startle response
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Reflex
Startle
Endocrinology
Diabetes and Metabolism
Pulsatile flow
Pituitary-Adrenal System
Rats
Sprague-Dawley
Stress Disorders
Post-Traumatic
03 medical and health sciences
chemistry.chemical_compound
Basal (phylogenetics)
0302 clinical medicine
Endocrinology
Corticosterone
Internal medicine
medicine
Animals
Circadian rhythm
Maze Learning
Glucocorticoids
Biological Psychiatry
Ultradian rhythm
Post-traumatic stress disorder (PTSD)
medicine.diagnostic_test
Endocrine and Autonomic Systems
Ultradian Rhythm
medicine.disease
Rats
Psychiatry and Mental health
Disease Models
Animal
030104 developmental biology
Phenotype
chemistry
Acoustic Stimulation
Disease Susceptibility
Psychology
030217 neurology & neurosurgery
Biomarkers
Stress
Psychological
Hormone
Zdroj: Psychoneuroendocrinology. 87
ISSN: 1873-3360
Popis: The basal activity of the hypothalamic-pituitary-adrenal axis is highly dynamic and is characterized by both circadian and ultradian (pulsatile) patterns of hormone secretion. Pulsatility of glucocorticoids has been determined to be critical for optimal transcriptional, neuroendocrine, and behavioral responses. We used an animal model of post-traumatic stress disorder (PTSD) to assess whether stress-induced impairment of behavioral responses is correlated with aberrant secretion of corticosterone. Serial blood samples were collected manually via the jugular vein cannula during the light-(inactive)-phase in conscious male rats at 20-min intervals for a period of 5h before and 6.5h after exposure to predator scent stress. The outcome measures included behavior in an elevated plus-maze and acoustic startle response 7days after exposure. Individual animals were retrospectively classified as having "extreme", "partial", or "minimal" behavioral responses according to pre-set cut-off criteria for behavioral response patterns. Corticosterone secretion patterns were analyzed retrospectively. Under basal conditions, the amplitude of ultradian oscillations of corticosterone levels, rather than the mean corticosterone level or the frequency of corticosterone pulsatility, was significantly reduced in individuals who displayed PTSD-phenotype 8days later. In addition, extreme disruption of behavior on day 8 post-exposure was also characterized by a blunting of corticosterone response to the stressor. Animals with behavior that was only partially affected or unaffected displayed none of the above changes. Blunted basal corticosterone pulse amplitude is a pre-existing susceptibility or risk factor for PTSD, which originates from prior (life) experiences and may therefore predict post-exposure PTSD-phenotype in rats.
Databáze: OpenAIRE
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