Intramuscular triamcinolone for difficult asthma
| Autor: | Jonathan Grigg, Priti Kenia, Jayachandran R. Panickar, Michael Silverman |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Triamcinolone acetonide Time Factors Adolescent medicine.drug_class Prednisolone Anti-Inflammatory Agents Injections Intramuscular Triamcinolone Acetonide Patient Admission medicine Humans Dose Reduced Child Glucocorticoids Asthma Retrospective Studies Asthma exacerbations business.industry Respiratory disease Retrospective cohort study medicine.disease Treatment Outcome Anesthesia Child Preschool Pediatrics Perinatology and Child Health Corticosteroid Female Difficult asthma business Biomarkers medicine.drug Follow-Up Studies |
| Zdroj: | Pediatric pulmonology. 39(5) |
| ISSN: | 8755-6863 |
| Popis: | We treated a selected group of children attending a difficult asthma clinic with intramuscular triamcinolone acetonide. This study retrospectively reviews markers of asthma severity in those who received one or more monthly doses for three periods: 1) 3 months preceding the first injection (pretreatment), 2) from the first injection to 1 month after the last injection (treatment period), and 3) 3 months after the treatment period (follow-up period). Severity markers during the treatment and follow-up periods were compared with the pretreatment period by paired t-test. Five children (5-13 years old) received a single dose, and 8 children (12-15 years old) received multiple doses. Multiple doses of triamcinolone (n = 3-5) were associated with a fall in the number of asthma exacerbations (P < 0.01) and hospital admissions (P < 0.01) in both the treatment and follow-up periods. A single dose reduced exacerbations (P < 0.05, treatment vs. pretreatment) but not hospital admissions. We conclude that intramuscular triamcinolone is a useful short-term therapy in difficult asthma. Whether its efficacy is due to improved compliance, or an improved anti-inflammatory profile compared with oral steroids, remains unclear. |
| Databáze: | OpenAIRE |
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