Temporal Cluster of Herpes Simplex Encephalitis: Investigation by Restriction Endonuclease Cleavage of Viral DNA
| Autor: | Adolf W. Karchmer, M. S. Hirsch, Bernard Roizman, T. G. Buchman, L. J. D'Angelo, Scott M. Hammer |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Adolescent Biopsy Biology Cleavage (embryo) chemistry.chemical_compound medicine Humans Simplexvirus Immunology and Allergy Dna viral General hospital Encephalitis Arbovirus Brain Herpes Simplex Middle Aged Endonucleases medicine.disease Virology Restriction enzyme Infectious Diseases chemistry DNA Viral Female Viral disease Encephalitis DNA Rare disease |
| Zdroj: | Journal of Infectious Diseases. 141:436-440 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Eight patients with brain biopsy-proven herpes simplex encephalitis were seen at the Massachusetts General Hospital, Boston, within a three-month period in the summer of 1977. The unusual temporal clustering of these cases engendered a formal epidemiologic investigation. No significant link among these patients was uncovered, and analysis of the cleavage products of seven of the eight viral isolates produced by the restriction endonucleases HsuI and HpaI showed that they were different. This cluster thus appears to have been a random event. Its occurrence, however, emphasizes that herpes encephalitis is not a rare disease in this country. In addition, the utility of restriction enzyme cleavage of DNA in clarifying the epidemiology of viral disease is underscored. |
| Databáze: | OpenAIRE |
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