Vascular Influence on Ventral Telencephalic Progenitors and Neocortical Interneuron Production
| Autor: | Wei Shi, Wenying Angela Liu, Zhizhong Li, Keith N. Brown, Xin Tan, Xin-Jun Zhang, Si-Qiang Ren, Song-Hai Shi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Telencephalon
0301 basic medicine Interkinetic nuclear migration Interneuron Green Fluorescent Proteins Gestational Age Mice Transgenic Neocortex Inhibitory postsynaptic potential Article General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences Glutamatergic 0302 clinical medicine Neural Stem Cells Interneurons Pregnancy medicine Animals Molecular Biology Embryonic Stem Cells biology Integrin beta1 musculoskeletal neural and ocular physiology fungi Neurogenesis Median Eminence Cell Biology Anatomy Preoptic Area Recombinant Proteins Parvalbumins 030104 developmental biology medicine.anatomical_structure nervous system biology.protein GABAergic Female Somatostatin Neuroglia Neuroscience 030217 neurology & neurosurgery Parvalbumin Developmental Biology |
| Zdroj: | Developmental Cell. 36:624-638 |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2016.02.023 |
| Popis: | The neocortex contains glutamatergic excitatory neurons and γ-aminobutyric acid (GABA)ergic inhibitory interneurons. Extensive studies have revealed substantial insights into excitatory neuron production. However, our knowledge of the generation of GABAergic interneurons remains limited. Here we show that periventricular blood vessels selectively influence neocortical interneuron progenitor behavior and neurogenesis. Distinct from those in the dorsal telencephalon, radial glial progenitors (RGPs) in the ventral telencephalon responsible for producing neocortical interneurons progressively grow radial glial fibers anchored to periventricular vessels. This progenitor-vessel association is robust and actively maintained as RGPs undergo interkinetic nuclear migration and divide at the ventricular zone surface. Disruption of this association by selective removal of INTEGRIN β1 in RGPs leads to a decrease in progenitor division, a loss of PARVALBUMIN and SOMATOSTATIN-expressing interneurons, and defective synaptic inhibition in the neocortex. These results highlight a prominent interaction between RGPs and periventricular vessels important for proper production and function of neocortical interneurons. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|