Concomitant Use of Rosuvastatin and Eicosapentaenoic Acid Significantly Prevents Native Coronary Atherosclerotic Progression in Patients With In-Stent Neoatherosclerosis
| Autor: | Yoichiro Sugizaki, Yoichiro Matsuoka, Hiromasa Otake, Yu Takahashi, Akira Nagasawa, Koji Kuroda, Hiroyuki Kawamori, Shinsuke Nakano, Ryo Takeshige, Kosuke Tanimura, Ken-ichi Hirata, Yusuke Fukuyama, Takayoshi Toba |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Eicosapentaenoic acid medicine.medical_treatment Neoatherosclerosis Subgroup analysis Coronary Artery Disease 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Percutaneous Coronary Intervention Intensive therapy Internal medicine Neointima medicine Humans Rosuvastatin In patient 030212 general & internal medicine Prospective Studies Rosuvastatin Calcium Lipoprotein cholesterol Aged Aged 80 and over Optical coherence tomography business.industry Anticholesteremic Agents Stent Drug-Eluting Stents General Medicine Atherosclerosis Plaque Atherosclerotic Treatment Outcome Concomitant Disease Progression Drug Therapy Combination Female Cardiology and Cardiovascular Medicine business Tomography Optical Coherence medicine.drug Follow-Up Studies |
| Zdroj: | Circulation Journal. 84(10):1826-1836 |
| ISSN: | 1346-9843 |
| Popis: | Background: In-stent neoatherosclerosis (NA) is a risk for future cardiovascular events through atherosclerotic progression in non-stented lesions. Using optical coherence tomography, this study assessed the efficacy of intensive therapy with 10 mg/day rosuvastatin plus 1,800 mg/day eicosapentaenoic acid (EPA) vs. standard 2.5 mg/day rosuvastatin therapy on native coronary plaques in patients with NA. Methods and Results: This was a subgroup analysis of the randomized LINK-IT trial, which was designed to compare changes in the lipid index in NA between intensive and standard therapy for 12 months. In all, 42 patients with native coronary plaques and NA were assessed. Compared with standard therapy, intensive therapy resulted in greater decreases in serum low-density lipoprotein cholesterol concentrations and greater increases in serum 18-hydroxyeicosapentaenoic acid concentrations, with significantly greater decreases in the lipid index and macrophage grade in both NA (-24 vs. 217 [P |
| Databáze: | OpenAIRE |
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