Influence of Estradiol Status on Physical Activity in Premenopausal Women
| Autor: | Robert S. Schwartz, Wendy M. Kohrt, Kathleen M. Gavin, Edward L. Melanson, Ellie Gibbons, Margaret E. Wierman, Kate Lyden, Pamela Wolfe |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Physical activity 030209 endocrinology & metabolism Physical Therapy Sports Therapy and Rehabilitation Ovary Gonadotropin-releasing hormone Placebo Proof of Concept Study Article law.invention Gonadotropin-Releasing Hormone 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Internal medicine medicine Humans Orthopedics and Sports Medicine Exercise physiology Exercise Estradiol business.industry Resistance Training Middle Aged 030104 developmental biology medicine.anatomical_structure Premenopause Female business Body mass index Hormone |
| Zdroj: | Medicine & Science in Sports & Exercise. 50:1704-1709 |
| ISSN: | 1530-0315 0195-9131 |
| DOI: | 10.1249/mss.0000000000001598 |
| Popis: | PURPOSE: To determine the effects of 5 months of ovarian hormone suppression in pre-menopausal women on objectively measured physical activity (PA). METHODS: Participants (age = 35±8 yr; body mass index = 27±6 kg·m(−2)) received monthly intramuscular injections of gonadotropin releasing hormone agonist therapy (GnRH(AG)) which suppresses pituitary gonadotropins and results in suppression of ovarian sex hormones. Women were randomized to receive concurrent transdermal E(2) (GnRH(AG)+E(2); n=30) or placebo (GnRH(AG)+PL, n=31). PA was assessed for 1 week before and during each month of the 5-month intervention using a hip-worn accelerometer (Actical, Mini Mitter Co., Inc., Bend, OR). Estimates of time spent in sedentary, light, and moderate-to-vigorous physical activity (MVPA) were derived using a previously published equation. Subsets of participants in each group were also randomized to a supervised progressive resistance exercise training program. RESULTS: Total MVPA tended towards being higher (p=0.08) in the GnRH(AG)+E(2) group at month 4. There were no significant effects of intervention or time in sedentary or light PA. In the subset of women who did not participate in structured exercise training for which Actical data were obtained (N=16 in each group), total MVPA was higher at month 4 (p=0.01). CONCLUSION: Physical activity levels appear to be maintained at a higher level in women undergoing pharmacological suppression of ovarian function with E(2) add back when compared with women treated with placebo. These data provide proof of concept data that E(2) contributes to the regulation of PA in humans. However, given the exploratory nature of this study, future confirmatory investigations will be necessary. |
| Databáze: | OpenAIRE |
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