Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
| Autor: | Guillermo López-Lluch, Daniel J. M. Fernández-Ayala, Plácido Navas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Mitochondrial Turnover Ubiquinone Inflammation Disease Review Mitochondrion Cytokine storm Biochemistry Proinflammatory cytokine Mitochondrial health 03 medical and health sciences 0302 clinical medicine Endocrinology medicine Genetics Animals Humans Molecular Biology business.industry SARS-CoV-2 Mitochondrial turnover COVID-19 Cell Biology medicine.disease Inflammaging Mitochondria Pneumonia Ageing 030104 developmental biology Immunology Metabolic syndrome medicine.symptom Mitochondrial nutrients business Cytokine Release Syndrome 030217 neurology & neurosurgery |
| Zdroj: | Experimental Gerontology Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense cytokine storm leading finally to a multi-organ failure and death. Comorbidities such as metabolic syndrome, obesity, type 2 diabetes, lung and cardiovascular diseases, all of them age-associated diseases, increase the severity and lethality of COVID-19. Mitochondrial dysfunction is one of the hallmarks of aging and COVID-19 risk factors. Dysfunctional mitochondria is associated with defective immunological response to viral infections and chronic inflammation. This review discuss how mitochondrial dysfunction is associated with defective immune response in aging and different age-related diseases, and with many of the comorbidities associated with poor prognosis in the progression of COVID-19. We suggest here that chronic inflammation caused by mitochondrial dysfunction is responsible of the explosive release of inflammatory cytokines causing severe pneumonia, multi-organ failure and finally death in COVID-19 patients. Preventive treatments based on therapies improving mitochondrial turnover, dynamics and activity would be essential to protect against COVID-19 severity. Highlights • Mitochondrial dysfunction is associated with aging and age-related diseases and metabolic syndrome. • Unbalanced activity of mitochondria is involved in inflammation and dysfunctional response to virus infection. • COVID-19 severity is higher in aged and metabolic syndrome related diseases. • Improvement of mitochondrial activity during aging can improve response to virus infections including respiratory virus. • Reduction of dysfunctional mitochondria can reduce the inflammatory response to SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
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