An in vitro analysis of a sustained release system for the treatment of denture stomatitis
| Autor: | Thomas R. Schneid |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Nystatin
Antifungal Agents Tissue Conditioning Dental Dentistry Denture Liners Pharmacology Incubation period Hardness Tensile Strength Candida albicans Materials Testing Ultimate tensile strength medicine Methylmethacrylates Clotrimazole Fluconazole General Dentistry Stomatitis Analysis of Variance business.industry Chlorhexidine medicine.disease Stomatitis Denture Corpus albicans Delayed-Action Preparations business medicine.drug |
| Zdroj: | Special Care in Dentistry. 12:245-250 |
| ISSN: | 1754-4505 0275-1879 |
| DOI: | 10.1111/j.1754-4505.1992.tb00458.x |
| Popis: | This study investigated the feasibility of a sustained-release delivery system for the treatment of denture stomatitis using four antifungal agents (chlorhexidine, clotrimazole, fluconazole, and nystatin) incorporated into a tissue conditioner (Lynal®) at zero (control), low, medium, and high concentrations. Hardness of all experimental groups increased with both concentration and time, but remained within the range of clinical acceptability (Shore A ≤ 49). Mean tensile strength increased in all experimental groups and was significantly stronger than the control for at least one concentration level of each drug, p ≤ 0.05. All failures for tensile-strength testing were characterized as cohesive. All drugs demonstrated release from the tissue conditioner matrix and inhibition of growth of C. albicans that was either total, dose-related, or related to incubation time prior to inoculation. All controls supported growth. |
| Databáze: | OpenAIRE |
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