Synthesis and reactivity of solid-supported organotrifluoroborates in Suzuki cross-coupling
| Autor: | Marc Presset, Virginie Colombel, Daniel Oehlrich, Frederik Rombouts, Gary A. Molander |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Ion exchange Molecular Structure Hydrocarbons Halogenated Aryl Organic Chemistry Halide Biochemistry Combinatorial chemistry Catalysis Article chemistry.chemical_compound chemistry Bromide Borates Organic chemistry Molecule Reactivity (chemistry) Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Organic letters. 14(7) |
| ISSN: | 1523-7052 |
| Popis: | Solid-supported organotrifluoroborates were prepared in high yields by ion exchange with Amberlyst resins. The reactivity of solid supported aryltrifluoroborates was evaluated in Suzuki–Miyaura couplings with numerous aryl bromide partners. Electron-rich and -poor substituents were tolerated on both substrates, providing yields up to 90%. Examples of alkyl-, alkenyl-, alkynyl-, and heteroaryltrifluoborates were also successfully cross-coupled to aryl halides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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