Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects
| Autor: | Francesco Violi, Andreina Petruccioli, Lorenzo Loffredo, Francesco Angelico, Daniele Pastori, Simona Bartimoccia, Roberto Monticolo, Roberto Cangemi, Roberto Carnevale, Pasquale Pignatelli, Cristina Nocella |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Ldl cholesterol
medicine.medical_specialty animal structures business.industry Endocrinology Diabetes and Metabolism digestive oral and skin physiology Healthy subjects Metabolism medicine.disease Obesity Endocrinology Internal medicine Diabetes mellitus Internal Medicine Medicine lipids (amino acids peptides and proteins) Original Article Metabolic syndrome medicine.symptom business Body mass index Weight gain reproductive and urinary physiology |
| Zdroj: | Nutrition & Diabetes |
| ISSN: | 2044-4052 |
| Popis: | Objectives: Extra virgin olive oil (EVOO) is a key component of the Mediterranean diet and seems to account for the protective effect against cardiovascular disease. However, the underlying mechanism is still elusive. Design: We tested the effect of EVOO, added to Mediterranean-type meal, on post-prandial glycemic and lipid profile. Subjects: Post-prandial glycemic and lipid profile were investigated in 25 healthy subjects who were randomly allocated in a cross-over design to a Mediterranean-type meal added with or without 10 g EVOO (first study), or Mediterranean-type meal with EVOO (10 g) or corn oil (10 g; second study). Glycemic profile, which included glucose, insulin, dipeptidyl-peptidase-4 (DPP-4) protein and activity, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), and lipid profile, which included, low-density lipoprotein (LDL) cholesterol (LDL-C), oxidized LDL (ox-LDL), triglycerides and high-density lipoprotein (HDL) cholesterol (HDL-C), were analyzed before and 2 h after the meal. Results: In the first study, 2 h after meal, subjects who assumed a meal with EVOO had significantly lower blood glucose (PPPPPPPPPPPPPPP Conclusions: We report for the first time that EVOO improves post-prandial glucose and LDL-C, an effect that may account for the antiatherosclerotic effect of the Mediterranean diet. |
| Databáze: | OpenAIRE |
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