Polyneuropathy: A Rare and Challenging Presentation of Essential Mixed Cryoglobulinemia
Autor: | Jason Meckler, Roaa Ahmed, Gianna Meckler, Ahmed Taha, Mohamed Taha, Narothama Aeddula |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Medicine (General) medicine.medical_specialty peripheral neuropathy Epidemiology Case Report Gastroenterology Polyneuropathies R5-920 Internal medicine ankylosing spondylitis Pathology medicine RB1-214 Humans Safety Risk Reliability and Quality Ankylosing spondylitis medicine.diagnostic_test business.industry Electromyography Peripheral Nervous System Diseases Magnetic resonance imaging Middle Aged medicine.disease Cryoglobulinemia Peripheral neuropathy medicine.anatomical_structure glucose-6-phosphate dehydrogenase Etiology bone marrow replacement Renal biopsy Bone marrow business Safety Research Polyneuropathy |
Zdroj: | Journal of Investigative Medicine High Impact Case Reports Journal of Investigative Medicine High Impact Case Reports, Vol 9 (2021) |
ISSN: | 2324-7096 |
Popis: | A 49-year-old male presented with acute chronic sensory motor bilateral lower extremity polyneuropathy. Electromyography showed bilateral acute sensory motor axonal polyneuropathy. Lumbar spine magnetic resonance imaging showed diffuse bone marrow replacement and bilateral ankylosing spondylitis. Laboratory workup revealed elevated inflammatory markers and low G6PD (glucose-6-phosphate dehydrogenase) level. Due to elevated acute phase reactants, inflammatory polyneuropathy was suspected; patient was treated accordingly with resolution of neuropathy. Three months later, he relapsed and presented with disabling polyneuropathy and renal impairment, which prompted renal biopsy. Renal histopathology revealed the, otherwise mysterious, etiology, essential mixed cryoglobulinemia. Essential mixed cryoglobulinemia was not considered initially due to the absence of classic systemic manifestations of autoimmune disorders. |
Databáze: | OpenAIRE |
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