Cerebral magnetic resonance imaging findings in adults with haemolytic uraemic syndrome following an infection with Escherichia coli, subtype O104:H4
Autor: | Bernd Eckert, Christian Gerloff, Joachim Röther, M. Meier-Cillien, Jens Fiehler, Tim Magnus, U. Löbel, Olga Simova, Stefan Kluge |
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Rok vydání: | 2013 |
Předmět: |
Male
Pathology medicine.medical_specialty Neurology Splenium Corpus callosum Sensitivity and Specificity Diagnosis Differential Neuroimaging Centrum semiovale medicine Humans Radiology Nuclear Medicine and imaging Escherichia coli Infections Neuroradiology medicine.diagnostic_test business.industry Brain Reproducibility of Results Magnetic resonance imaging Middle Aged medicine.disease Diffusion Magnetic Resonance Imaging Enterohemorrhagic Escherichia coli Hemolytic-Uremic Syndrome Encephalitis Female Neurology (clinical) business |
Zdroj: | Clinical neuroradiology. 24(2) |
ISSN: | 1869-1447 |
Popis: | Infections with Enterohaemorrhagic Escherichia coli typically occur in children causing haemolytic uraemic syndrome (HUS) and neurological symptoms in 20–50 %. Little information is available on the morphology of brain manifestations in adults. The purpose of this study was to identify a characteristic magnetic resonance imaging (MRI) pattern during the outbreak of a novel mutation of Escherichia coli O104:H4. Patients were recruited from two hospitals between May and July 2011. The MRI protocol included standard anatomical, diffusion-weighted, and susceptibility-sensitive sequences. A total of 104 MRIs of 57 (32 female, 25 male) patients (mean 45.5 ± 18.4 years) showed abnormal signal intensity on 51 MRIs (49 %). Bilateral thalamus (39 %), bilateral pons (35 %), centrum semiovale and splenium of corpus callosum (33 %) were most often involved. Acute lesions were reversible in 81 % of cases. There was no statistically significant association between symptom onset and the MRI findings (P = 0.2). Neuroimaging findings in this adult patient cohort were non-specific and similar to previous findings in children. A characteristic neuroimaging pattern of an infection with Escherichia coli O104:H4 was not identified. However, bilateral symmetric T2 hyperintense lesions of the thalami and dorsal pons characterized by restricted diffusion suggest a metabolic toxic effect of the disease on the brain. |
Databáze: | OpenAIRE |
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