Use of different immunosuppressive strategies in recipients of kidneys from nonheart-beating donors
| Autor: | Julia Blanco, Ana Sánchez-Fructuoso, Alberto Barrientos, J. Conesa, M. Marques, N. Ridao, A. Rodríguez |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Graft Rejection Male Nephrology medicine.medical_specialty Daclizumab medicine.medical_treatment Azathioprine Antibodies Monoclonal Humanized Gastroenterology Tacrolimus Internal medicine medicine Humans Acute tubular necrosis Retrospective Studies Transplantation business.industry Graft Survival Antibodies Monoclonal Immunosuppression Middle Aged Mycophenolic Acid Lipid Metabolism medicine.disease Kidney Transplantation Tissue Donors Surgery Survival Rate Creatinine Immunoglobulin G Cytomegalovirus Infections Cyclosporine Drug Therapy Combination Female Steroids business Complication Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplant International. 18:596-603 |
| ISSN: | 1432-2277 0934-0874 |
| DOI: | 10.1111/j.1432-2277.2005.00100.x |
| Popis: | Summary In nonheart-beating donor (NHBD) kidney transplants, immunosuppressive management is difficult mainly because of the high incidence of acute tubular necrosis. This has meant that since the start of our NHBD transplant program, several immunosuppression regimes have been used. The aim of this retrospective study was to evaluate the results obtained over 7 years using different treatment protocols. A total of 172 consecutive NHBD transplants performed between April 1996 and December 2002 were treated as follows: G-I (n = 21), cyclosporine (8 mg/kg/day) plus azathioprine plus steroids; G-II (n = 65), low-dose cyclosporine (5 mg/kg/day) plus mycophenolate plus steroids; G-III (n =17), low-dose tacrolimus (0.1 mg/kg/day) plus mycophenolate plus steroids; and G-IV (n = 69), daclizumab plus low-dose tacrolimus plus mycophenolate plus steroids. Delayed graft function rates were 76.2%, 72.3%, 76.5%, and 42%, respectively, for the four groups (P = 0.000). Rejection-free patient rates were 76.2%, 46.2%, 35.3%, and 71% (P |
| Databáze: | OpenAIRE |
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