Structure and mechanism of AMPA receptor — auxiliary protein complexes
| Autor: | Eric Gouaux, Shanshuang Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Chemistry Protein subunit Glutamate receptor Kainate receptor AMPA receptor Neurotransmission Article Cell biology Protein Subunits 03 medical and health sciences 0302 clinical medicine nervous system Structural Biology Animals NMDA receptor Receptors AMPA Receptor Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology Ionotropic effect |
| Zdroj: | Current Opinion in Structural Biology. 54:104-111 |
| ISSN: | 0959-440X |
| Popis: | Ionotropic glutamate receptors in vertebrates are composed of three major subtypes - AMPA, kainate, and NMDA receptors - and mediate the majority of fast excitatory neurotransmission at chemical synapses of the central nervous system. Among the three major families, native AMPA receptors function as complexes with a variety of auxiliary subunits, which in turn modulate receptor trafficking, gating, pharmacology, and permeation. Despite the long history of structure-mechanism studies using soluble receptor domains or intact yet isolated receptors, structures of AMPA receptor-auxiliary subunit complexes have not been available until recent breakthroughs in single-particle cryo-electron microscopy. Single particle cryo-EM studies have, in turn, provided new insights into the structure and organization of AMPA receptor - auxiliary protein complexes and into the molecular mechanisms of AMPA receptor activation and desensitization. |
| Databáze: | OpenAIRE |
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