Regulation of cortical blood flow responses by the nucleus basalis of Meynert during nociceptive processing
| Autor: | Mathieu Piché, Thierry Paquette, Hugues Leblond, Ryota Tokunaga, Sara Touj |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Diagnostic Imaging
Male 0301 basic medicine Blood Pressure Stimulation Somatosensory system Nucleus basalis 03 medical and health sciences 0302 clinical medicine medicine Animals Rats Wistar Cerebral Cortex Basal forebrain business.industry General Neuroscience Somatosensory Cortex General Medicine Sciatic Nerve Acetylcholine Electric Stimulation Rats 030104 developmental biology medicine.anatomical_structure nervous system Cerebral blood flow Cerebral cortex Somatosensory evoked potential Basal Nucleus of Meynert Cerebrovascular Circulation Sciatic nerve business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Research. 149:22-28 |
| ISSN: | 0168-0102 |
| Popis: | Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in systemic mean arterial pressure (MAP). The objective of this study was to investigate the contribution of NBM to CBF responses evoked by nociceptive electrical stimuli and how it may be affected by systemic MAP. CBF was recorded in isoflurane-anesthetized rats (n = 8) using laser speckle contrast imaging, in two conditions (intact vs left NBM lesion). Electrical stimulation was applied to the sciatic nerve. Sciatic stimulation produced intensity dependent increases in MAP (p 0.001) that were almost identical between conditions (intact vs left NBM lesion; p = 0.96). In both conditions, sciatic stimulation produced intensity dependent CBF increases (p 0.001). After NBM lesion, CBF responses were decreased in the left somatosensory cortex ipsilateral to NBM lesion (p = 0.02) but not in the right somatosensory cortex (p = 0.46). These results indicate that NBM contributes to CBF responses to nociceptive stimulation in the ipsilateral, but not contralateral somatosensory cortex and that CBF response attenuation by NBM lesion is not compensated passively by systemic MAP changes. This highlights the importance of NBM's integrity for pain-related hemodynamic responses in the somatosensory cortex. |
| Databáze: | OpenAIRE |
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