Antitumor Activity of Phenylahistinin Vitroandin Vivo
| Autor: | Jun Katada, Michiko Muramatsu, Yoshio Hayashi, Isao Uno, Shinkichi Kohno, Kaneo Kanoh |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Diketopiperazines Biology Pharmacology Applied Microbiology and Biotechnology Biochemistry Piperazines Analytical Chemistry Carcinoma Lewis Lung Mice chemistry.chemical_compound In vivo Tumor Cells Cultured Animals Molecular Biology Antibiotics Antineoplastic Leukemia P388 Cell Cycle Organic Chemistry Lewis lung carcinoma Stereoisomerism Biological activity General Medicine Cell cycle In vitro chemistry Stereoselectivity Enantiomer Biotechnology Plinabulin |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 63:1130-1133 |
| ISSN: | 1347-6947 0916-8451 |
| Popis: | Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC50 values ranging from 1.8 x 10(-7) to 3.7 x 10(-6), while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo. |
| Databáze: | OpenAIRE |
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