Role of adropin in arterial stiffening associated with obesity and type 2 diabetes

Autor:	Thomas J. Jurrissen, Francisco I. Ramirez-Perez, Francisco J. Cabral-Amador, Rogerio N. Soares, Ryan J. Pettit-Mee, Edgar E. Betancourt-Cortes, Neil J. McMillan, Neekun Sharma, Helena N. M. Rocha, Shumpei Fujie, Mariana Morales-Quinones, Yoskaly Lazo-Fernandez, Andrew A. Butler, Subhashis Banerjee, Harold S. Sacks, Jamal A. Ibdah, Elizabeth J. Parks, R. Scott Rector, Camila Manrique-Acevedo, Luis A. Martinez-Lemus, Jaume Padilla
Rok vydání:	2022
Předmět:	Mice Knockout Physiology Endothelial Cells Nitric Oxide Actins Mesenteric Arteries Mice Inbred C57BL Mice Vascular Stiffness Diabetes Mellitus Type 2 Physiology (medical) Animals Humans Obesity Nitric Oxide Synthase Peptides Cardiology and Cardiovascular Medicine
Zdroj:	American Journal of Physiology-Heart and Circulatory Physiology. 323:H879-H891
ISSN:	1522-1539 0363-6135
DOI:	10.1152/ajpheart.00385.2022
Popis:	Adropin is a peptide largely secreted by the liver and known to regulate energy homeostasis; however, it also exerts cardiovascular effects. Herein, we tested the hypothesis that low circulating levels of adropin in obesity and type 2 diabetes (T2D) contribute to arterial stiffening. In support of this hypothesis, we report that obesity and T2D are associated with reduced levels of adropin (in liver and plasma) and increased arterial stiffness in mice and humans. Establishing causation, we show that mesenteric arteries from adropin knockout mice are also stiffer, relative to arteries from wild-type counterparts, thus recapitulating the stiffening phenotype observed in T2D
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7064f696e54b677f7e59ffa567c26a2c https://doi.org/10.1152/ajpheart.00385.2022 Zobrazit plný text záznamu