How to select the right patients for focal therapy of prostate cancer?
| Autor: | Thomas J. Polascik, Niccolò M. Passoni |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Ablation Techniques
Image-Guided Biopsy Male Oncology medicine.medical_specialty Urology medicine.medical_treatment Disease Prostate cancer Breast cancer Predictive Value of Tests Risk Factors Prostate Internal medicine Biopsy medicine Humans medicine.diagnostic_test Index Lesion business.industry Patient Selection Lumpectomy Prostatic Neoplasms Cancer medicine.disease Magnetic Resonance Imaging Treatment Outcome medicine.anatomical_structure Surgery Computer-Assisted Neoplasm Grading business Organ Sparing Treatments |
| Zdroj: | Current Opinion in Urology. 24:203-208 |
| ISSN: | 0963-0643 |
| DOI: | 10.1097/mou.0000000000000045 |
| Popis: | Purpose of review Just as lumpectomy for breast cancer aims at achieving oncological control with maximal tissue preservation, the concept of focal therapy for prostate cancer has evolved with the aim of controlling disease while preserving urinary and erectile function. Our review aims at describing the evolution of focal therapy in time and the resulting advances in patient selection. Recent findings Originally, focal therapy was developed as an alternative to active surveillance for men with low-risk disease and a minimal burden of cancer. However, with improvement of the diagnostic technologies, the entry criteria for this therapeutic approach are broadening. Since its introduction, focal therapy has evolved from ablation of half or three-quarters of the prostate in men with low-risk disease to only selected cancer foci even if they present with Gleason pattern 4. This development has become possible because of a better understanding of the biology of the index lesion(s) and the improvement of biopsy techniques. Candidates were selected at first with conventional transrectal random prostate biopsies. To overcome the sampling bias of standard techniques, a more thorough multicore sampling utilizing transperineal three-dimensional template mapping biopsies was developed. Today, advances in multiparametric MRI allow for detection and targeted biopsies of high-grade and high-volume lesions. Summary In light of the less stringent selection criteria, enrollment for focal therapy protocols should encourage patient education on the need of possible subsequent cycles of ablation as well as the need for surveillance of the untreated prostatic tissue, as prostate cancer is transformed into a chronic, manageable condition. |
| Databáze: | OpenAIRE |
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