Repetitive blast mild traumatic brain injury increases ethanol sensitivity in male mice and risky drinking behavior in male combat veterans
| Autor: | Abigail G. Schindler, Larry S. Zweifel, David G. Cook, Britahny M. Baskin, Paul E. M. Phillips, Rebecca C. Hendrickson, Kathleen F. Pagulayan, Elaine R. Peskind, Barbara Juarez, Murray A. Raskind, Suhjung Janet Lee |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Alcohol Drinking medicine.drug_class Traumatic brain injury media_common.quotation_subject 030508 substance abuse Medicine (miscellaneous) Male mice Alcohol use disorder Toxicology Impulsivity Article Mice Young Adult 03 medical and health sciences 0302 clinical medicine Blast Injuries Recurrence Risk Factors medicine Animals Cluster Analysis Humans Sensation seeking Brain Concussion Veterans media_common War Exposure Behavior Animal Ethanol business.industry Addiction Central Nervous System Depressants Middle Aged medicine.disease Alcoholism Psychiatry and Mental health Sedative Hazardous drinking medicine.symptom 0305 other medical science business Locomotion 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Alcohol Clin Exp Res |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/acer.14605 |
| Popis: | Background Mild traumatic brain injury (mTBI) is common in civilians and highly prevalent among military service members. mTBI can increase health risk behaviors (e.g., sensation seeking, impulsivity) and addiction risk (e.g., for alcohol use disorder (AUD)), but how mTBI and substance use might interact to promote addiction risk remains poorly understood. Likewise, potential differences in single vs. repetitive mTBI in relation to alcohol use/abuse have not been previously examined. Methods Here, we examined how a history of single (1×) or repetitive (3×) blast exposure (blast-mTBI) affects ethanol (EtOH)-induced behavioral and physiological outcomes using an established mouse model of blast-mTBI. To investigate potential translational relevance, we also examined self-report responses to the Alcohol Use Disorders Identification Test-Consumption questions (AUDIT-C), a widely used measure to identify potential hazardous drinking and AUD, and used a novel unsupervised machine learning approach to investigate whether a history of blast-mTBI affected drinking behaviors in Iraq/Afghanistan Veterans. Results Both single and repetitive blast-mTBI in mice increased the sedative properties of EtOH (with no change in tolerance or metabolism), but only repetitive blast potentiated EtOH-induced locomotor stimulation and shifted EtOH intake patterns. Specifically, mice exposed to repetitive blasts showed increased consumption "front-loading" (e.g., a higher rate of consumption during an initial 2-h acute phase of a 24-h alcohol access period and decreased total daily intake) during an intermittent 2-bottle choice condition. Examination of AUDIT-C scores in Iraq/Afghanistan Veterans revealed an optimal 3-cluster solution: "low" (low intake and low frequency), "frequent" (low intake and high frequency), and "risky" (high intake and high frequency), where Veterans with a history of blast-mTBI displayed a shift in cluster assignment from "frequent" to "risky," as compared to Veterans who were deployed to Iraq/Afghanistan but had no lifetime history of TBI. Conclusions Together, these results offer new insight into how blast-mTBI may give increase AUD risk and highlight the increased potential for adverse health risk behaviors following repetitive blast-mTBI. |
| Databáze: | OpenAIRE |
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