Evidence for human herpesvirus 6 variant A antibodies in multiple sclerosis: diagnostic and therapeutic implications
| Autor: | Antti Vaheri, Markus Färkkilä, Anne J. Jääskeläinen, Jussi Oskari Virtanen, Lasse Uotila, Marjaleena Koskiniemi, Juha Multanen |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Multiple Sclerosis Herpesvirus 6 Human Fluorescent Antibody Technique Roseolovirus Infections Antibodies Viral Immunoglobulin G Serology Central nervous system disease 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cerebrospinal fluid Seroepidemiologic Studies Virology Medicine Humans 030304 developmental biology 0303 health sciences biology business.industry Multiple sclerosis medicine.disease biology.organism_classification 3. Good health Neurology Immunology Acute Disease DNA Viral biology.protein Human herpesvirus 6 Female Neurology (clinical) Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Journal of neurovirology. 13(4) |
| ISSN: | 1355-0284 |
| Popis: | Human herpesvirus 6 (HHV-6) has been linked to the pathogenesis of multiple sclerosis (MS). HHV-6 antibodies in serum and cerebrospinal fluid (CSF) of 27 patients with clinically definite MS (CDMS) were compared with age- and sex-matched controls, including various other neurological diseases and symptoms (OND). In addition, we studied a series of 19 patients with clinically or laboratory supported possible MS (CPMS). Seroprevalence to HHV-6A was 100% in patients with MS, both in CDMS and CPMS, compared to 69.2% in patients with OND (P = .001 and .007). The mean immunoglobulin G (IgG) titers were significantly higher in patients with CDMS and CPMS than in controls (P = .005 and .00002). The proportion of acute primary infections without CSF involvement was similar in all groups; however, primary infections with intrathecal HHV-6 antibody production were more frequent in MS. In CSF, HHV-6A-specific antibodies were present in three (11.5%) and four (21.1%) patients with CDMS and CPMS, compared to none with OND (P = .06 and .01, respectively). Serological suggestions to HHV-6A infection occurred more often in both CDMS and CPMS than in OND (14.8% versus 21.1% versus 3.8%). We conclude that a subpopulation of MS patients, and even a greater proportion of possible MS subjects, has serological evidence of HHV-6A infection, which might provide new markers for diagnosis and therapy. |
| Databáze: | OpenAIRE |
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