Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signalling
| Autor: | Zi Nan, Jie Yin, Dingfu Xiao, Wei Gao, Wenkai Ren, Gang Liu, Peng Bin, Shuai Chen, Xionggui Hu, Jianhua He |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Intestinal microbiota medicine.drug_class Antibiotics Medicine (miscellaneous) Context (language use) macromolecular substances Pharmacology Biology Microbiology Jejunum Chitosan 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine RAR-related orphan receptor gamma medicine TX341-641 PI3K/AKT/mTOR pathway Nutrition and Dietetics Nutrition. Foods and food supply technology industry and agriculture FOXP3 equipment and supplies carbohydrates (lipids) IL-17 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis mTOR Interleukin 17 Food Science |
| Zdroj: | Journal of Functional Foods, Vol 22, Iss, Pp 166-176 (2016) |
| ISSN: | 1756-4646 |
| Popis: | This study was conducted to explore the effect of chitosan supplementation on mouse intestinal microbiota and interleukin-17 (IL-17) expression. Chitosan supplementation reduced mouse body weight, associating with change of intestinal microbiota (i.e. lowering the ratio of Firmicutes: Bacteroidetes). In antibiotics treated mice, chitosan supplementation had little effect on mouse body weight. Chitosan supplementation decreased expression of IL-17 in mouse jejunum and inhibited the mTOR pathway. In antibiotics treated mice, chitosan also reduced expression of IL-17 in the jejunum. Activation of mTOR signalling in mouse increased expression of IL-17 in the jejunum in the context of chitosan supplementation. We conclude that chitosan supplementation reduces mouse body weight through the intestinal microbiota, and inhibits intestinal IL-17 expression through the mTOR signalling. The discovery of this study suggests the potentials of chitosan as a functional supplement in intestinal health. |
| Databáze: | OpenAIRE |
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