Rates of sustained virological response 12 weeks after the scheduled end of direct-acting antiviral (DAA)-based hepatitis C virus (HCV) therapy from the National German HCV registry: does HIV coinfection impair the response to DAA combination therapy?
| Autor: | Christiane Cordes, Jenny Bischoff, Michael P. Manns, A Moll, Stefan Mauss, Markus Cornberg, A Baumgarten, Thomas Lutz, Juergen K. Rockstroh, H Jäger, Stefan Scholten |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Combination therapy Sustained Virologic Response Hepatitis C virus HIV Infections medicine.disease_cause Antiviral Agents Drug Administration Schedule Virological response Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Germany medicine Humans Pharmacology (medical) 030212 general & internal medicine Registries Aged Hepatitis HIV Coinfection business.industry Health Policy Age Factors virus diseases Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease CD4 Lymphocyte Count Infectious Diseases Treatment Outcome Cohort 030211 gastroenterology & hepatology Female business |
| Zdroj: | HIV medicine. 19(4) |
| ISSN: | 1468-1293 |
| Popis: | The European Association for the Study of the Liver (EASL) treatment recommendations for hepatitis C no longer discriminate between HIV/hepatitis C virus (HCV)-coinfected and HCV-monoinfected patients. However, recent data from Spain are questioning these recommendations on the basis of the findings of higher relapse rates and lower cure rates in HIV/HCV-infected subjects. The aim of our study was to compare HCV cure rates in monoinfected and coinfected patients from Germany.Data acquired from the Deutsches Hepatitis C-Registry were analysed. A total of 5657 HCV-monoinfected subjects and 488 HIV/HCV-coinfected patients were included in the study. Rates of sustained virological response 12 weeks after the scheduled end of therapy (SVR12) were collected in both subgroups and in cirrhotic and noncirrhotic patients.HIV/HCV-coinfected patients were more frequently male (84.6% vs. 56.4%, respectively; P 0.001) and younger than HCV-monoinfected subjects (46.5 ± 9 vs. 53.8 ± 12.5 years, respectively; P 0.001). The CD4 blood cell count was 350 cells/μL in 63.1% of HIV-positive subjects and 88.7% were on antiretroviral therapy. SVR12 rates were 90.3% (5111 of 5657) in our HCV-monoinfected cohort and 91.2% (445 of 488) in our coinfected patients. Liver cirrhosis was confirmed in 1667 of 5657 (29.5%) monoinfected patients and 84 of 488 (17.2%; P 0.001) coinfected patients. SVR12 rates did not differ between HCV-monoinfected and HIV/HCV-coinfected patients with liver cirrhosis (87.8% vs. 89.3%, respectively; P = 0.864). A treatment duration of 8 weeks did not reduce the percentage of patients with SVR12 in either subgroup (93.7% in both groups).We found high SVR12 rates in monoinfected as well as coinfected individuals. No differences were detected between the two subgroups regardless of whether there was accompanying liver cirrhosis or a shortened treatment duration. |
| Databáze: | OpenAIRE |
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