Articular Cartilage Restoration Requires Cells, Scaffolds, Growth Factors, and Mechanical Stimulation
| Autor: | Jefferson C. Brand, Mark G. Siegel, James H. Lubowitz, Michael J. Rossi |
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| Rok vydání: | 2021 |
| Předmět: |
Cartilage
Articular Scaffold Fractures Stress Stimulation Extracellular matrix 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tissue engineering Hyaluronic acid Medicine Humans Orthopedics and Sports Medicine Prospective Studies Fibrin glue 030222 orthopedics Tissue Engineering Tissue Scaffolds business.industry Sealant Mesenchymal stem cell 030229 sport sciences Allografts Extracellular Matrix chemistry business Biomedical engineering |
| Zdroj: | Arthroscopy : the journal of arthroscopicrelated surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 37(5) |
| ISSN: | 1526-3231 |
| Popis: | Tissue engineering requires cells, scaffolds, growth factors, and mechanical stimulation. In terms of cartilage restoration or repair, various innovative approaches are evolving, using host or allograft cells, biomimetic scaffolds, matrices, or membranes including hyaluronic acid, as well as diverse biological and growth factors. A current approach for the treatment of chondral or osteochondral defects enhances a microfracture procedure (introducing autologous, mesenchymal stem cells) with dehydrated micronized allograft extracellular matrix (scaffold), platelet-rich plasma (containing anabolic, anticatabolic, and anti-inflammatory growth factors), a fibrin glue sealant, and careful rehabilitation providing mechanical stimulation. Early results are encouraging; long-term outcomes including a larger number of study subjects remain to be reported. |
| Databáze: | OpenAIRE |
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