Atypical teratoid/rhabdoid tumor in adult: case series and an integrated survival analysis
| Autor: | Ni Chen, Ya Xing Chen, Yi Cao, Jian Han Huang, Shu Cai Fan, Liangxue Zhou, Ai Jun Peng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Series (stratigraphy) Chemotherapy business.industry medicine.medical_treatment Adult case General Medicine medicine.disease Radiation therapy 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Atypical teratoid rhabdoid tumor medicine Surgery Neurology (clinical) business 030217 neurology & neurosurgery Survival analysis |
| Zdroj: | British Journal of Neurosurgery. :1-16 |
| ISSN: | 1360-046X 0268-8697 |
| DOI: | 10.1080/02688697.2021.1885620 |
| Popis: | Atypical teratoid/rhabdoid tumor (AT/RT) is well documented in children but less so in adults because of its rarity.We report a series of five cases, a literature review and quantitative analysis of the survival outcome of adult AT/RT patients.Seventy-four patients including our five cases (male: female = 16: 58) were evaluated, whose median age was 32.5 years (18-80 years). The commonest location was the sellar region. Median overall survival (OS) was 12.5 months (0.5-204.00 months). Chemotherapy was associated with OS (HR: 0.349, 95%CI: 0.176-0.694,Adult AT/RT is commoner in females and tends to recur rapidly after surgical resection. Chemotherapy may provide a survival benefit. Surgery combined with postoperative chemotherapy and radiotherapy was associated with better prognosis for adult AT/RT patients, though the overall prognosis was still poor. |
| Databáze: | OpenAIRE |
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