Renal Dysfunction After Liver Transplantation: Effect of Donor Type
| Autor: | Florence Wong, Shuet Fong Neong, David R. Grant, Anand Ghanekar, Bettina E. Hansen, Markus Selzner, Mamatha Bhat, Ian D. McGilvray, Roizar Rosales, Nazia Selzner, Stuart A. McCluskey, Mark S. Cattral, Les Lilly, Gonzalo Sapisochin, Dagmar Kollmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Brain Death medicine.medical_treatment Urology Renal function 030230 surgery Liver transplantation Severity of Illness Index End Stage Liver Disease 03 medical and health sciences Liver disease chemistry.chemical_compound 0302 clinical medicine medicine Living Donors Humans Renal replacement therapy Retrospective Studies Transplantation Creatinine Hepatology business.industry Hazard ratio Graft Survival Acute kidney injury Original Articles Middle Aged medicine.disease Tissue Donors Liver Transplantation chemistry 030211 gastroenterology & hepatology Surgery Original Article business Kidney disease Longterm Outcomes |
| Zdroj: | Liver Transplantation |
| ISSN: | 1527-6473 1527-6465 |
| Popis: | Recipients of donation after circulatory death (DCD) grafts are reportedly at higher risk of developing renal dysfunction after liver transplantation (LT). We compared the development of acute kidney injury (AKI) and chronic kidney disease (CKD) after LT in recipients of DCD versus donation after brain death (DBD) or living donor liver transplantation (LDLT) livers. Adult recipients of DBD, LDLT, and DCD between 2012 and 2016 at Toronto General Hospital were included. AKI was defined as a post‐LT increase of serum creatinine (sCr) ≥26.5 µmol/L within 48 hours or a ≥50% increase from baseline, and CKD was defined as an estimated glomerular filtration rate 3 months. A total of 681 patients (DCD, n = 57; DBD, n = 446; and LDLT, n = 178) with similar baseline comorbidities were included. Perioperative AKI (within the first 7 postoperative days) was observed more frequently in the DCD group (61%; DBD, 40%; and LDLT, 44%; P = 0.01) and was associated with significantly higher peak AST levels (P |
| Databáze: | OpenAIRE |
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