Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters
| Autor: | Andréa Vaz Braga Pintor, Isleine Portal Caldas, Marcela Baraúna Magno, Emanuelle Stellet Lourenço, Miriam F. Zaccaro Scelza, Sandro Tavares, Emanuele Di Edoardo, Carlos Fernando de Almeida Barros Mourão, Gutemberg Gomes Alves, Pietro Montemezzi, Fabiano Palmeira Gonçalves, Pantaleo Scelza, Fernanda Nunes |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Technology
Regenerative endodontics Radiography Dentistry Article dentition permanent law.invention Randomized controlled trial systematic review law Medicine General Materials Science Pulp necrosis Microscopy QC120-168.85 Dentition business.industry Incidence (epidemiology) QH201-278.5 Engineering (General). Civil engineering (General) TK1-9971 meta-analysis Descriptive and experimental mechanics Meta-analysis Pulp (tooth) regenerative endodontics Electrical engineering. Electronics. Nuclear engineering TA1-2040 business |
| Zdroj: | Materials, Vol 14, Iss 4418, p 4418 (2021) Materials Volume 14 Issue 16 |
| ISSN: | 1996-1944 |
| Popis: | This work aimed to investigate the use of Regenerative Endodontic Procedures (REP) on the treatment of pulp necrosis in mature teeth through systematic review and meta-analysis of evidence on clinical and radiographic parameters before and after REP. A search was performed in different databases on 9 September 2020, including seven clinical studies and randomized controlled trials (RCT). The methodological quality was assessed using Revised Cochrane risk-of-bias (RoB 2) and Before-and-After tools. Meta-analyses were performed to evaluate the success incidences regarding the reduction of periapical lesion and recovery of sensitivity. The certainty of the evidence was assessed using GRADE. Meta-analysis showed a high overall success of 0.95 (0.92, 0.98) I2 = 6%, with high periapical lesion reduction at 12 months (0.93 (0.86, 0.96) I2 = 37%) and by the end of follow-up (0.91 (0.83, 0.96) I2 = 13%). Lower incidences of positive sensitivity response were identified for the electrical (0.58 (0.46, 0.70) I2 = 51%) and cold tests (0.70 (0.54, 0.84) I2 = 68%). The calculated levels of REP success were similar to those reported for immature teeth. With a very low certainty of evidence, the meta-analysis showed a high incidence of REP’s success for mature teeth with necrotic pulp evidenced by periapical lesion reduction and moderate positive responses to sensitivity tests. |
| Databáze: | OpenAIRE |
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