Fasciolaantigens as vaccines against fascioliasis and schistosomiasis
| Autor: | George V. Hillyer |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Fascioliasis
Helminthiasis Schistosomiasis Cross Reactions Fatty Acid-Binding Proteins Saposins Antigen parasitic diseases Vaccines DNA medicine Animals Humans Fasciola hepatica Glutathione Transferase Vaccines biology Fasciola General Medicine biology.organism_classification medicine.disease Cathepsins Virology Schistosomiasis mansoni Vaccination Antigens Helminth Immunology Animal Science and Zoology Parasitology Schistosoma mansoni Trematoda |
| Zdroj: | Journal of Helminthology. 79:241-247 |
| ISSN: | 1475-2697 0022-149X |
| DOI: | 10.1079/joh2005304 |
| Popis: | Fascioliasis is an important trematode infection of herbivores worldwide with increasing evidence of prevalence as a disease of humans. Vaccination studies with purified native and recombinantFasciolaantigens suggest that this approach to diminished morbidity and mortality and reduced transmission is a realistic goal. Among the major potential vaccine candidates are fatty acid binding protein (FABP), cysteine (cathepsin) proteases, haemoglobulin, leucine aminopeptidase, and a saposin-like protein. In the case ofFasciola hepaticaFABP, cross-reaction and cross-protection againstSchistosoma mansoniis an important feature. In addition to protective effects with significant worm burden reductions, some vaccine candidates also have anti-fecundity (smaller flukes), anti-pathology (less liver lesions), and anti-embryonation effects. Optimism is tempered by the fact that fascioliasis in humans is an orphan disease and in need of governmental and foundation support. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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