Initial Clinical Experience with Stationary Digital Breast Tomosynthesis
| Autor: | Otto Zhou, Suk Jung Kim, Beilin Jia, Donglin Zeng, Jianping Lu, Yueh Z. Lee, Cherie M. Kuzmiak, Ruth Walsh, Connor Puett, Connie Kim, Sora C. Yoon, Christina R. Inscoe |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Digital mammography Multivariate analysis Breast imaging Population Breast Neoplasms Multimodal Imaging Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Image Processing Computer-Assisted medicine Humans Mammography Radiology Nuclear Medicine and imaging Medical physics Breast education education.field_of_study Modality (human–computer interaction) medicine.diagnostic_test Receiver operating characteristic Nanotubes Carbon business.industry Middle Aged Radiographic Image Enhancement 030220 oncology & carcinogenesis Female Microcalcification medicine.symptom business |
| Zdroj: | Acad Radiol |
| ISSN: | 1076-6332 |
| DOI: | 10.1016/j.acra.2018.12.026 |
| Popis: | Rationale and Objectives: A linear array of carbon nanotube-enabled x-ray sources allows for stationary digital breast tomosynthesis (sDBT), during which projection views are collected without the need to move the x-ray tube. This work presents our initial clinical experience with a first-generation sDBT device. Materials and Methods: Following informed consent, women with a “suspicious abnormality” (Breast Imaging Reporting and Data System 4), discovered by digital mammography and awaiting biopsy, were also imaged by the first generation sDBT. Four radiologists participated in this paired-image study, completing questionnaires while interpreting the mammograms and sDBT image stacks. Areas under the receiver operating characteristic curve were used to measure reader performance (likelihood of correctly identifying malignancy based on pathology as ground truth), while a multivariate analysis assessed preference, as readers compared one modality to the next when interpreting diagnostically important image features. Results: Findings from 43 women were available for analysis, in whom 12 cases of malignancy were identified by pathology. The mean areas under the receiver operating characteristic curve was significantly higher (p < 0.05) for sDBT than mammography for all breast density categories and breast thicknesses. Additionally, readers preferred sDBT over mammography when evaluating mass margins and shape, architectural distortion, and asymmetry, but preferred mammography when characterizing microcalcifications. Conclusion: Readers preferred sDBT over mammography when interpreting soft-tissue breast features and were diagnostically more accurate using images generated by sDBT in a Breast Imaging Reporting and Data System 4 population. However, the findings also demonstrated the need to improve microcalcification conspicuity, which is guiding both technological and image-processing design changes in future sDBT devices. |
| Databáze: | OpenAIRE |
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